Common cold (Acute Rhinosinusitis) virtually non-existant when Vitamin D is above 50 ng – Oct 2015

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Association of Vitamin D Status and Acute Rhinosinusitis: Results From the United States National Health and Nutrition Examination Survey 2001–2006

Medicine: October 2015 - Volume 94 - Issue 40 - p e1447, doi: 10.1097/MD.0000000000001447
Khalid, Ayesha N. MD, MBA; Ladha, Karim S. MD; Luong, Amber U. MD, PhD; Quraishi, Sadeq A. MD, MHA, MMSc

Although vitamin D status may be a modifiable risk factor for various respiratory ailments, limited data exists regarding its role in sinonasal infections. Our goal was to investigate the association of 25-hydroxyvitamin D (25OHD) levels with acute rhinosinusitis (ARS) in a large, nationally representative sample of non-institutionalized individuals from the United States.

In this cross-sectional study of individuals ≥17 years from the National Health and Nutrition Examination Survey 2001–2006, we used multivariable regression analysis to investigate the association of 25OHD levels with ARS,
while adjusting for

• season,
• demographics
  (age, sex, race, and poverty-to-income ratio), and
• clinical data
  (smoking, asthma, chronic obstructive pulmonary disease, diabetes mellitus, and neutropenia).

A total of 3921 individuals were included in our analyses. Median 25OHD level was 22 (interquartile range 16–28) ng/mL. Overall, 15.8% (95% confidence interval [CI] 14.4–17.7) of participants reported ARS within the 24 hours leading up to their survey participation. After adjusting for season, demographics, and clinical data, 25OHD levels were associated with ARS (odds ratio 0.88, 95% CI 0.78–0.99 per 10 ng/mL).
When vitamin D status was dichotomized, 25OHD levels <20 ng/mL were associated with 33% higher odds of ARS (odds ratio 1.33, 95% CI 1.03–1.72) compared with levels ≥20 ng/mL.

Our analyses suggest that 25OHD levels are inversely associated with ARS. Randomized, controlled trials are warranted to determine the effect of optimizing vitamin D status on the risk of sinonasal infections.
 Download the PDF from VitaminDWiki

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Study cited 13 times as of Aug 2025

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• Acute Respiratory Tract Infection and 25-Hydroxyvitamin D Concentration: A Systematic Review and Meta-Analysis - Aug 2019 FREE PDF   has data up to only 34 ng
• The Immunomodulatory Role of Vitamin D in Respiratory Diseases - Sept 2019 FREE PDF

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See also VitaminDWiki

• Immune response to respiratory viruses – vitamin D connection – review May 2015
• Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
• Respiratory infections (RTI) cut in half by 20,000 IU weekly vitamin D if initially deficient – RCT March 2015
• Respiratory diseases helped by vitamin D if initially have low level – RCT review Jan 2015
• Colds not decreased if people already vitamin D sufficient – RCT Oct 2012
• Review of common cold (42 billion dollars) prevention and treatment - Zinc works – Feb 2014
• Overview Colds and flu and Vitamin D includes information on Vitamin C and Zinc
• Reduction in Cold and Flu with Vitamin D which has the following

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