Monthly Increase in Vitamin D Levels upon Supplementation with 2000 IU/Day in Healthy Volunteers: Result from “Integriamoci”, a Pilot Pharmacokinetic Study
Molecules 2022, 27(3), 1042; https://doi.org/10.3390/molecules27031042
by Valeria Avataneo 1ORCID,Alice Palermiti 1ORCID,Amedeo De Nicolò 1,*ORCID,Jessica Cusato 1ORCID,Gloria Giussani 2,Andrea Calcagno 3ORCID andAntonio D’Avolio 1ORCID
1 Laboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, Amedeo di Savoia Hospital, University of Turin, 10126 Turin, Italy
2 Witt Italia S.p.A., 10046 Poirino, Italy
3 Unit of Infectious Diseases, Department of Medical Sciences, University of Turin, 10124 Turin, Italy
Vitamin D (VD) is a calcium- and phosphate-controlling hormone used to treat bone disorders; yet, several other effects are progressively emerging. VD deficiency is highly prevalent worldwide, with suboptimal exposure to sunlight listed among the leading causes: oral supplementation with either cholecalciferol or calcitriol is used. However, there is a scarcity of clinical studies investigating how quickly VD concentrations can increase after supplementation. In this pilot study, the commercial supplement ImmuD3 (by Erboristeria Magentina®) was chosen as the source of VD and 2000 IU/day was administered for one month to 21 healthy volunteers that had not taken any other VD supplements in the previous 30 days. Plasma VD levels were measured through liquid chromatography coupled to tandem mass spectrometry after 7, 14, and 28 days of supplementation. We found that 95% of the participants had insufficient VD levels at baseline (<30 ng/mL; median 23.72 ng/mL; IQR 18.10–26.15), but after 28 days of supplementation, this percentage dropped to 62% (median 28.35 ng/mL; IQR 25.78–35.20). The median increase in VD level was 3.09 ng/mL (IQR 1.60–5.68) after 7 days and 8.85 ng/mL (IQR 2.85–13.97F) after 28 days. This study suggests the need for continuing VD supplementation and for measuring target level attainment.
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VitaminDWiki pages with RESPONSE in title (130 as of Feb 2022)
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Items found: 177
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Activation (methylation) of CYP2R1 and CYP24A1 predict response to dose of vitamin D – Oct 2013 |
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24 Feb, 2015 |
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Transdermal Magnesium Chloride spray - variable responses, removed toxic metals - 2010 |
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21 Jan, 2015 |
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Solutions if have poor response to conventional vitamin D |
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14 Dec, 2014 |
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Immune System response of infants is associated with higher levels of vitamin D – RCT Nov 2014 |
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08 Nov, 2014 |
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How to predict response to a vitamin D dose – RCT April 2014 |
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06 Nov, 2014 |
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Not as much dark skin vitamin D response from single UV dose (no surprise) – Oct 2013 |
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13 Aug, 2014 |
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Dose response equations for Vitamin D |
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02 Aug, 2014 |
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Response to vitamin D dose, overview of 25 studies - Feb 2014 |
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02 Aug, 2014 |
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Similar response to Vitamin D supplements by senior white and black women – Feb 2013 |
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08 May, 2014 |
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U-shaped response to vitamin D – possible causes |
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24 Apr, 2014 |
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Response to high dose vitamin D is limited by vitamin A - July 2013 |
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13 Apr, 2014 |
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Hypothesis: Low vitamin D is responsible for many recent increases in health problems |
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01 Jan, 2014 |
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Hypothesis: Magnesium accounts for some of the variation in vitamin D response – Oct 2013 |
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16 Nov, 2013 |
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40 percent less likely to get adequate vitamin D response if have certain genes – Jan 2013 |
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10 Sep, 2013 |
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Increased D levels responsible for Dead Sea therapy – May 2011 |
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16 Aug, 2013 |
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Response to vitamin D related to DBP and CYP2RI genes – Aug 2013 |
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10 Aug, 2013 |
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Response to Vitamin D3 varied with rs4588, D2 less response than D3 and did not change – April 2013 |
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13 Jul, 2013 |
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Difference in Fok gene reduced response to vitamin D by 35 percent – Nov 2012 |
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17 Nov, 2012 |
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Response by Masterjohn on vitamin A thwarting vitamin D – Mar 2010 |
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26 Oct, 2012 |
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Is Vitamin D Supplementation Responsible for the Allergy Pandemic – May 2012 |
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27 Jun, 2012 |
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Metabolites and genes may predict responses to Calcium and Vitamin D – Jan 2011 |
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24 Jun, 2012 |
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40 ng response plateau to 2000 to 4,000 IU of vitamin D – June 2012 |
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19 Jun, 2012 |
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More response to 1100 IU vitamin D in cold season or less BMI – May 2012 |
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15 May, 2012 |
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Miss Ohio Teen USA on responsible tanning |
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29 Sep, 2010 |
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Genetics Determines Vitamin D Response |
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19 Aug, 2010 |
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Hormesis: response to dose may not be linear |
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16 Jun, 2010 |
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Would be nice to capture and share vitamin D dose /response / benefit information |
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24 May, 2010 |