Autism severity is associated with each of low Vitamins D, A, B-12 and E – Sept 2024

Interaction and association between multiple vitamins and social adaptability and severity of autism: A large-scale retrospective study from China

Autism Res. 2024 Sep 26. doi: 10.1002/aur.3241. rent the PDF for $15
Qi Liu 1 2, Dongchuan Yu 1 2 3

Since children with autism spectrum disorder (ASD) often exhibit selective eating behaviors, it is generally believed that they may have abnormal nutrient structure, leading to aberrant concentrations of some serum vitamins. However, previous studies on serum vitamins in individuals with ASD are mixed. Additionally, the interaction and association between multiple serum vitamin and ASD-related symptoms remain unclear. This study utilized a cross-sectional survey with a large sample size (n = 1235) from China to clarify previous mixed findings, and examine the interaction and association between multiple serum vitamins (including

  • folic acid [FA],
  • vitamin A [VA],
  • vitamin E [VE],
  • vitamin B12 [VB12], and
  • vitamin D [VD])

and social adaptability and symptom severity in children with ASD.
Findings found that symptom severity was negatively associated with concentrations of serum

  • VA,
  • VE,
  • VB12, and
  • VD; while,

social adaptability was significantly associated with the natural log-transformed concentrations of FA and VB12.
Finding also revealed the interaction of VA and VE on the association between both vitamins and severity of ASD symptoms, as well as the interaction of VB12 and FA on the association between both vitamins and social adaptability. In particular, the combination of low concentration of VA and high concentration of VE is associated with the lowest risk of being "severely autistic"; while, the combination of low concentration of FA and high concentration of VB12 is associated with the lowest risk of being "poor social adaptability". This study offers the evidence for the requirement of considering multiple vitamins comprehensively, as well as valuable references for revealing the association between vitamin disparities and food selectivity in children with ASD.

17 Autism risk factors: low Vitamin D, virus, vaccine, mercury etc. - many studies

VitaminDWiki – Vitamin A category listing has 71 items along with the following map

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VitaminDWiki – Vitamin B12 contains

Vitamin B12 is not a cofactor of Vitamin D, but it is often needed with Vitamin D
Surfing the web finds

  • B12 deficiency increases with age
  • B12 appears to have no toxic upper limit
  • Some people get frequent B12 injections or I.V to restore levels
    • Injection probably be needed
  • Only a small portion of B12 taken orally gets into the bloodstream
  • B12 is stored in the liver – half-life of > 2 years - But. Dr. Greger says to take it weekly or daily
  • B12 deficiency symptoms include poor gut - which can reduce uptake of Vitamin D
    • unless use gut-friendly forms of Vitamin D, including topical
  • B12 can be supplemented via pills, sublingual, transdermal patch, injection, emulsion, and spray
    • As with Vitamin D, a massive (loading) dose can restore levels quickly
    • Nano forms of B12 are more bio-available - as with many other supplements
  • Vitamin D and Vitamin B-12 are synergistic VitaminDWiki
62 items in Vitamin B12 category on VitaminDWiki

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