50,000 IU of Vitamin D every 2 weeks reduced gestational diabetes – RCT Feb 2015

Supplementation of Vitamin D in Pregnancy and its Correlation with feto-maternal outcome

Clinical Endocrinology, DOI: 10.1111/cen.12751
Aanchal Sablok1,*, Aruna Batra1, Karishma Thariani1, Achla Batra1, Rekha Bharti1, Abha Rani Aggarwal2, BC Kabi3 and Harish Chellani4
1 Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
2 National Institute of Medical Statistics, All India Institute of Medical Sciences, New Delhi, India
3 Department of Biochemistry, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
4 Department of Paediatrics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India

  • Corresponding author: Dr. Aanchal Sablok, Senior Resident, Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi. 110029, India. aanchalsablok54@gmail.com

VitaminDWiki Summary
ControlIntervention
Vitamin D Level 18 ng 32 ng
Preterm labor
or Pre-eclampsia
or Gestational Diabetes 		44 % 20 %
Birth weight 2.4 kg2.6 kg

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Context: Vitamin D deficiency is widely prevalent throughout the world. Pregnant women, neonates, and infants form the most vulnerable groups for vitamin D deficiency.

Objective: 1) To find the prevalence of vitamin D deficiency in pregnant women. 2) To evaluate the effect of supplementation with cholecalciferol in improving vitamin D levels in pregnant women and evaluate its correlation with feto-maternal outcome.

Design: Randomized control trial from the years 2010-2012.

Setting: Tertiary care center, Delhi, India.

Participants: 180 pregnant women. The study population was divided randomly into 2 groups; Group A: non-intervention (60 women) and Group B: intervention (120 women).

Intervention: The intervention group received supplementation of vitamin D in dosages depending upon 25(OH)-D levels.

Main Outcome Measures: Risk of maternal complications like Preterm labor, pre-eclampsia, and gestational diabetes associated with Vitamin D deficiency and risk of Low birth weight and poor APGAR score in infants of mothers with Vitamin D deficiency.

Results: Adjusted serum 25(OH)-D concentration was lower in group A as compared to group B (mean 46.11 ± 74.21 nmol/L vs 80 ± 51.53 nmol/L). 44% of patients in group A and 20.3% of patients in group B developed Pre-term labor/Pre-eclampsia/Gestational Diabetes. New-borns of mothers in group A had lower cord blood levels of 25(OH)-D levels as compared to group B (mean 43.11 ± 81.32 nmol/L vs 56.8 ± 47.52 nmol/L). They also had lower birth weight of mean 2.4 ± 0.38 kg as compared to group B 2.6 ± 0.33 kg.

Conclusions: Vitamin D supplementation reduces the risk of maternal comorbidities and helps improve neonatal outcomes.

See also VitaminDWiki

Healthy pregnancies need lots of vitamin D the following summary
Most were taking 2,000 to 7,000 IU daily for >50% of pregnancy
   Click on hyperlinks for details

Problem
Vit. D
Reduces		Evidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits		 RCT
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

VitaminDWiki with GESTATIONAL DIABETES in the title (36 as of July 2022)

This list is automatically updated

Items found: 40

229+ VitaminDwiki pages have 50,000 or 60,000 IU in their title

Note: India uses 60,000 IU capsules

Items found: 266
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60,000 IU vitamin D monthly with daily Calcium was safe but not enough in the winter – 2012 02 Nov, 2013
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